The study included 110 patients diagnosed with HS and 110 healthy individuals who did not receive any vitamin D supplements over the last year were recruited and included in the study. Thus, this study aimed to assess serum vitamin D levels in patients with Hidradenitis suppurativa in Jordan.Ī cross-sectional comparative study was conducted among patients of the Department of Dermatology, Jerash Hospital, between April 2018 and March 2020. Similarly, there is a lack of relevant literature in Jordan. In general, there is a scarcity of evidence assessing the level of vitamin D and its association with HS. HS has a psychologically and clinically significant adverse effect on the patient’s quality of life. Lesions usually affect apocrine gland-bearing anatomical areas of the body and is characterized by painful, inflamed nodules or boils that progress to abscesses, sinus tracts, and scarring. Hidradenitis suppurativa (HS) "also known as acne inversa," is a chronic, recurrent, and debilitating inflammatory skin condition, characterized by recurrent inflammatory nodules and abscesses due to follicular structural abnormalities that augmented by risk factors such as smoking, obesity, positive family history, and shaving. Moreover, despite the lack of literature, it was reported that vitamin D level was found to be lower in HS patients compared to the other population. Imbalance of vitamin D level has been associated with skin disorders like including atopic dermatitis, psoriasis, vitiligo, polymorphous light eruption, mycosis fungoides, alopecia areata, systemic lupus erythematosus, melanoma, and Hidradenitis suppurativa (HS), but the evidence was deemed speculative and inconclusive. In recent years, there has been a growing interest in the role played by vitamin D in skin disease. While genetic polymorphism has also been reported. In general, low sun exposure is considered as major risk factor for Vitamin D deficiency along with female gender and high BMI, and decreased physical activities. According to the US endocrine society guidelines, vitamin D deficiency is considered as serum level of less than 20ng/ml (50 nmol/L), while vitamin D level between 21-29ng/ml (52.5–72.5nmol/L) is vitamin D insufficiency. Low vitamin D level has been classified into two categories. Furthermore, Vitamin D plays multiple skin functions ranging from keratinocyte proliferation, differentiation, and apoptosis to barrier maintenance and immune-regulatory processes, making its supplementation useful in the management of various dermatologic conditions, including HS. But also, a protective factor in several diseases like hypertension, diabetes, cardiovascular diseases, autoimmune diseases, and cancers. Not only just it has an established role in mineral balance and skeletal maintenance. Vitamin D is a fat-soluble steroid hormone essential for human health. We suggest the implementation standard public dietary recommendations of Vitamin D supplementation, smoking cessation, and weight reduction behaviors with further assessment of disease course among HS patients. Smoking and high BMI, were associated with HS. Most of the study subjects and particularly all of the patients with HS have low vitamin D levels. Patients of HS were more likely to have vitamin D deficiency compared to healthy controls. The mean Vitamin D level was 8.4 ng/ml and all HS patients were vitamin D deficient. The mean body mass index among patients with HS was 30 and about 34% of them were smokers. The mean age of the cases was 43.1 ± 12.9 years and the mean disease duration was 19.4 months. Serum vitamin D was measured and classified into normal (>30 ng/ml), insufficient (20–30 ng/ml), and low (<20 ng/ml). a cross-sectional comparative study conducted among 110 patients with HS and 110 matched controls, who didn’t previously receive vitamin D therapy. We aimed to assess serum vitamin D levels in patients with (HS) in Jordan. Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the apocrine gland bearing skin, presenting various stages of flexural skin pain, erythema, painful nodules, abscesses, sinuses, and fistulas.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |